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DNA stretching in the nucleosome facilitates alkylation by an intercalating antitumour agent
DNA stretching in the nucleosome core can cause dramatic structural distortions, which may influence compaction and factor recognition in chromatin. We find that the base pair unstacking arising from stretching-induced extreme minor groove kinking near the nucleosome centre creates a hot spot for in...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2847236/ https://ncbi.nlm.nih.gov/pubmed/20026584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1174 |
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