Llwytho...

Stereochemical control of nucleosome targeting by platinum-intercalator antitumor agents

Platinum-based anticancer drugs act therapeutically by forming DNA adducts, but suffer from severe toxicity and resistance problems, which have not been overcome in spite of decades of research. And yet defined chromatin targets have generally not been considered in the drug development process. Her...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nucleic Acids Res
Prif Awduron: Chua, Eugene Y.D., Davey, Gabriela E., Chin, Chee Fei, Dröge, Peter, Ang, Wee Han, Davey, Curt A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477649/
https://ncbi.nlm.nih.gov/pubmed/25916851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv356
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