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The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization
Telomerase defers the onset of telomere damage-induced signaling and cellular senescence by adding DNA onto chromosome ends. The ability of telomerase to elongate single-stranded telomeric DNA depends on the reverse transcriptase domain of TERT, and also relies on protein:DNA contacts outside the ac...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2847226/ https://ncbi.nlm.nih.gov/pubmed/20034955 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1160 |
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