Transport of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine, a metabolite of trichloroethylene, by mouse multidrug resistance associated protein 2 (Mrp2)

N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine (Ac-DCVC) and S-(1,2-dichlorovinyl)-L-cysteine (DCVC) are the glutathione conjugation pathway metabolites of a common industrial contaminant and potent nephrotoxicant trichloroethylene (TCE). Ac-DCVC and DCVC are accumulated in the renal proximal tubule wher...

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Main Authors: Tsirulnikov, Kirill, Abuladze, Natalia, Koag, Myong-Chul, Newman, Debra, Scholz, Karoline, Bondar, Galyna, Zhu, Quansheng, Avliyakulov, Nuraly K., Dekant, Wolfgang, Faull, Kym, Kurtz, Ira, Pushkin, Alexander
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847015/
https://ncbi.nlm.nih.gov/pubmed/20060011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2009.12.035
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