Nelfinavir, an HIV-1 Protease Inhibitor, Induces Oxidative Stress–Mediated, Caspase-Independent Apoptosis in Leishmania Amastigotes

BACKGROUND: Visceral leishmaniasis has now emerged as an important opportunistic disease in patients coinfected with human immunodeficiency virus type-1 (HIV-1). Although the effectiveness of HIV-1 protease inhibitors, such as nelfinavir, in antiretroviral therapies is well documented, little is kno...

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Detalhes bibliográficos
Main Authors: Kumar, Pranav, Lodge, Robert, Trudel, Nathalie, Ouellet, Michel, Ouellette, Marc, Tremblay, Michel J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846936/
https://ncbi.nlm.nih.gov/pubmed/20361030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0000642
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