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Need-Based Up-Regulation of Protein Levels in Response to Deletion of Their Duplicate Genes

Many duplicate genes maintain functional overlap despite divergence over long evolutionary time scales. Deleting one member of a paralogous pair often has no phenotypic effect, unless its paralog is also deleted. It has been suggested that this functional compensation might be mediated by active up-...

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Autors principals: DeLuna, Alexander, Springer, Michael, Kirschner, Marc W., Kishony, Roy
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846854/
https://ncbi.nlm.nih.gov/pubmed/20361019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000347
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