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Discovery and design of DNA and RNA ligase inhibitors in infectious microorganisms
BACKGROUND: Members of the nucleotidyltransferase superfamily known as DNA and RNA ligases carry out the enzymatic process of polynucleotide ligation. These guardians of genomic integrity share a three-step ligation mechanism, as well as common core structural elements. Both DNA and RNA ligases have...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2846787/ https://ncbi.nlm.nih.gov/pubmed/20354588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/17460440903373617 |
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