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Discovery and design of DNA and RNA ligase inhibitors in infectious microorganisms

BACKGROUND: Members of the nucleotidyltransferase superfamily known as DNA and RNA ligases carry out the enzymatic process of polynucleotide ligation. These guardians of genomic integrity share a three-step ligation mechanism, as well as common core structural elements. Both DNA and RNA ligases have...

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Autors principals: Swift, Robert V., Amaro, Rommie E.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846787/
https://ncbi.nlm.nih.gov/pubmed/20354588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/17460440903373617
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