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Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei

Trypanosomatid RNA editing is a unique process and essential for these organisms. It therefore represents a drug target for a group of protozoa that includes the causative agents for African sleeping sickness and other devastating tropical and subtropical diseases. Here, we present drug-like inhibit...

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Bibliografiske detaljer
Main Authors: Amaro, Rommie E., Schnaufer, Achim, Interthal, Heidrun, Hol, Wim, Stuart, Kenneth D., McCammon, J. Andrew
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577703/
https://ncbi.nlm.nih.gov/pubmed/18981420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805820105
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