Pharmacokinetics of spiramycin in the rhesus monkey: transplacental passage and distribution in tissue in the fetus.

Transplacental transfer of spiramycin was investigated in a rhesus monkey model to study whether the antibiotic reaches therapeutic levels in the fetus. Spiramycin concentrations were measured by bioassay and high-performance liquid chromatography. Pharmacokinetic parameters were determined for bioa...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Schoondermark-Van de Ven, E, Galama, J, Camps, W, Vree, T, Russel, F, Meuwissen, J, Melchers, W
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1994
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284663/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7810999/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.9.1922
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