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Pharmacokinetics of spiramycin in the rhesus monkey: transplacental passage and distribution in tissue in the fetus.

Transplacental transfer of spiramycin was investigated in a rhesus monkey model to study whether the antibiotic reaches therapeutic levels in the fetus. Spiramycin concentrations were measured by bioassay and high-performance liquid chromatography. Pharmacokinetic parameters were determined for bioa...

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Bibliografiske detaljer
Main Authors: Schoondermark-Van de Ven, E, Galama, J, Camps, W, Vree, T, Russel, F, Meuwissen, J, Melchers, W
Format: Artigo
Sprog:Inglês
Udgivet: 1994
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC284663/
https://ncbi.nlm.nih.gov/pubmed/7810999
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