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Mapping the dynamics of ligand reorganization via (13)CH(3) and (13)CH(2) relaxation dispersion at natural abundance
Flexible ligands pose challenges to standard structure-activity studies since they frequently reorganize their conformations upon protein binding and catalysis. Here, we demonstrate the utility of side chain (13)C relaxation dispersion measurements to identify and quantify the conformational dynamic...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2846628/ https://ncbi.nlm.nih.gov/pubmed/19639385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10858-009-9349-4 |
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