Deciphering Protein Kinase Specificity through Large-Scale Analysis of Yeast Phosphorylation Site Motifs

Phosphorylation is a universal mechanism for regulating cell behavior in eukaryotes. Although protein kinases are known to target short linear sequence motifs on their substrates, the rules for kinase substrate recognition are not completely understood. We used a rapid peptide screening approach to...

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Main Authors: Mok, Janine, Kim, Philip M., Lam, Hugo Y. K., Piccirillo, Stacy, Zhou, Xiuqiong, Jeschke, Grace R., Sheridan, Douglas L., Parker, Sirlester A., Desai, Ved, Jwa, Miri, Cameroni, Elisabetta, Niu, Hengyao, Good, Matthew, Remenyi, Attila, Ma, Jia-Lin Nianhan, Sheu, Yi-Jun, Sassi, Holly E., Sopko, Richelle, Chan, Clarence S. M., De Virgilio, Claudio, Hollingsworth, Nancy M., Lim, Wendell A., Stern, David F., Stillman, Bruce, Andrews, Brenda J., Gerstein, Mark B., Snyder, Michael, Turk, Benjamin E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846625/
https://ncbi.nlm.nih.gov/pubmed/20159853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000482
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