In Vivo Cyclophosphamide and IL-2 Treatment Impedes Self-Antigen-Induced Effector CD4 Cell Tolerization: Implications for Adoptive Immunotherapy

The development of T cell tolerance directed toward tumor-associated Ags can limit the repertoire of functional tumor-reactive T cells, thus impairing the ability of vaccines to elicit effective antitumor immunity. Adoptive immunotherapy strategies using ex vivo expanded tumor-reactive effector T ce...

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Main Authors: Mihalyo, Marianne A., Doody, Amy D. H., McAleer, Jeremy P., Nowak, Elizabeth C., Long, Meixiao, Yang, Yi, Adler, Adam J.
Formato: Artigo
Idioma:Inglês
Publicado: 2004
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846334/
https://ncbi.nlm.nih.gov/pubmed/15100273
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