Alzheimer Precursor Protein Interaction with the Nogo-66 Receptor Reduces Amyloid-β Plaque Deposition

Pathophysiologic hypotheses for Alzheimer’s disease (AD) are centered on the role of the amyloid plaque Aβ peptide and the mechanism of its derivation from the amyloid precursor protein (APP). As part of the disease process, an aberrant axonal sprouting response is known to occur near Aβ deposits. A...

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Detalhes bibliográficos
Main Authors: Park, James H., Gimbel, David A., GrandPre, Tadzia, Lee, Jung-Kil, Kim, Ji-Eun, Li, Weiwei, Lee, Daniel H. S., Strittmatter, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846286/
https://ncbi.nlm.nih.gov/pubmed/16452662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3291-05.2006
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