Safety and immunogenicity of Salmonella typhimurium expressing C-terminal truncated human IL-2 in a murine model

Salmonella enterica serovar Typhimurium preferentially colonizes tumors in vivo and has proven to be an effective biologic vector. The attenuated S. enterica Typhimurium strain χ4550 was engineered to express truncated human interleukin-2 and renamed SalpIL2. Previously, we observed that a single or...

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Detalhes bibliográficos
Main Authors: Sorenson, Brent, Banton, Kaysie, Augustin, Lance, Barnett, Sean, McCulloch, Karen, Dorn, Joshua, Frykman, Natalie, Leonard, Arnold, Saltzman, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2010
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846145/
https://ncbi.nlm.nih.gov/pubmed/20376175
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