Macrolide antibiotics protect against endotoxin-induced vascular leakage and neutrophil accumulation in rat trachea.

We studied the effects of macrolides on lipopolysaccharide (LPS)-induced airway inflammation in the rat tracheal mucosa. Erythromycin and roxithromycin dose dependently inhibited microvascular leakage and neutrophil recruitment induced by LPS. This inhibitory action on vascular permeability was abol...

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Bibliographic Details

Published in:	Antimicrob Agents Chemother
Main Authors:	Tamaoki, J, Sakai, N, Tagaya, E, Konno, K
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 1994
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284605/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7979298/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.7.1641
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