DMP 323, a nonpeptide cyclic urea inhibitor of human immunodeficiency virus (HIV) protease, specifically and persistently blocks intracellular processing of HIV gag polyprotein.

DMP 323, a C-2-symmetrical cyclic urea, is representative of a new class of inhibitors of human immunodeficiency virus protease. In this study, we correlate the potent antiviral activity of DMP 323 in acute infections with antiprotease activity assessed by monitoring the inhibition of the processing...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Rayner, M M, Cordova, B C, Meade, R P, Aldrich, P E, Jadhav, P K, Ru, Y, Lam, P Y
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 1994
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284604/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7979297/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.7.1635
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