Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia

Resistance to thyroid hormone (RTH), a dominantly inherited disorder usually associated with mutations in thyroid hormone receptor β (THRB), is characterized by elevated levels of circulating thyroid hormones (including thyroxine), failure of feedback suppression of thyrotropin, and variable tissue...

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Main Authors: Mitchell, Catherine S., Savage, David B., Dufour, Sylvie, Schoenmakers, Nadia, Murgatroyd, Peter, Befroy, Douglas, Halsall, David, Northcott, Samantha, Raymond-Barker, Philippa, Curran, Suzanne, Henning, Elana, Keogh, Julia, Owen, Penny, Lazarus, John, Rothman, Douglas L., Farooqi, I. Sadaf, Shulman, Gerald I., Chatterjee, Krishna, Petersen, Kitt Falk
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846038/
https://ncbi.nlm.nih.gov/pubmed/20237409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38793
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