The Angiotensin IV Analog Nle-Tyr-Leu-ψ-(CH(2)-NH(2))(3-4)-His-Pro-Phe (Norleual) Can Act as a Hepatocyte Growth Factor/c-Met Inhibitor

The angiotensin (Ang) IV analog norleual [Nle-Tyr-Ile-ψ-(CH(2)-NH(2))(3-4)-His-Pro-Phe] exhibits structural homology with the hinge (linker) region of hepatocyte growth factor (HGF) and is hypothesized to act as a hinge region mimic. Norleual competitively inhibited the binding of HGF to its recepto...

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Autores principales: Yamamoto, B. J., Elias, P. D., Masino, J. A., Hudson, B. D., McCoy, A. T., Anderson, Z. J., Varnum, M. D., Sardinia, M. F., Wright, J. W., Harding, J. W.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2010
Materias:
Cellular and Molecular
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846015/
https://ncbi.nlm.nih.gov/pubmed/20086056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.161711
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