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HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes
Human T-cell leukemia virus type I (HTLV-I)–associated malignancies are seen in a small percentage of infected persons. Although in vitro immortalization by HTLV-I virus is very efficient, we report that Tax has poor oncogenic activity in human primary T cells and that immortalization by Tax is rare...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2845900/ https://ncbi.nlm.nih.gov/pubmed/20093405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-241117 |
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