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HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes

Human T-cell leukemia virus type I (HTLV-I)–associated malignancies are seen in a small percentage of infected persons. Although in vitro immortalization by HTLV-I virus is very efficient, we report that Tax has poor oncogenic activity in human primary T cells and that immortalization by Tax is rare...

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Bibliografske podrobnosti
Main Authors: Bellon, Marcia, Baydoun, Hicham H., Yao, Yuan, Nicot, Christophe
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845900/
https://ncbi.nlm.nih.gov/pubmed/20093405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-241117
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