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Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia

Eph receptors and their ephrin ligands are involved in normal hematopoietic development and tumorigenesis. Using methylated CpG island amplification/DNA promoter microarray, we identified several EPH receptor and EPHRIN genes as potential hypermethylation targets in acute lymphoblastic leukemia (ALL...

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Hlavní autoři: Kuang, Shao-Qing, Bai, Hao, Fang, Zhi-Hong, Lopez, Gonzalo, Yang, Hui, Tong, Weigang, Wang, Zack Z., Garcia-Manero, Guillermo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845899/
https://ncbi.nlm.nih.gov/pubmed/20061560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-222208
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