Phase I trial of valaciclovir, the L-valyl ester of acyclovir, in patients with advanced human immunodeficiency virus disease.

Valaciclovir, the L-valyl ester of acyclovir, is rapidly and extensively converted in humans to acyclovir after oral administration by first-pass metabolism. A phase I study was conducted in two cohorts of volunteers with advanced human immunodeficiency virus (HIV) disease (absolute CD4 lymphocyte c...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Jacobson, M A, Gallant, J, Wang, L H, Coakley, D, Weller, S, Gary, D, Squires, L, Smiley, M L, Blum, M R, Feinberg, J
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284589/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7979285/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.7.1534
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