Phase I trial of valaciclovir, the L-valyl ester of acyclovir, in patients with advanced human immunodeficiency virus disease.

Valaciclovir, the L-valyl ester of acyclovir, is rapidly and extensively converted in humans to acyclovir after oral administration by first-pass metabolism. A phase I study was conducted in two cohorts of volunteers with advanced human immunodeficiency virus (HIV) disease (absolute CD4 lymphocyte c...

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Bibliographic Details
Main Authors: Jacobson, M A, Gallant, J, Wang, L H, Coakley, D, Weller, S, Gary, D, Squires, L, Smiley, M L, Blum, M R, Feinberg, J
Format: Artigo
Language:Inglês
Published: 1994
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC284589/
https://ncbi.nlm.nih.gov/pubmed/7979285
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