Exoerythrocytic Plasmodium Parasites Secrete a Cysteine Protease Inhibitor Involved in Sporozoite Invasion and Capable of Blocking Cell Death of Host Hepatocytes

Plasmodium parasites must control cysteine protease activity that is critical for hepatocyte invasion by sporozoites, liver stage development, host cell survival and merozoite liberation. Here we show that exoerythrocytic P. berghei parasites express a potent cysteine protease inhibitor (PbICP, P. b...

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Detalhes bibliográficos
Main Authors: Rennenberg, Annika, Lehmann, Christine, Heitmann, Anna, Witt, Tina, Hansen, Guido, Nagarajan, Krishna, Deschermeier, Christina, Turk, Vito, Hilgenfeld, Rolf, Heussler, Volker T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845656/
https://ncbi.nlm.nih.gov/pubmed/20361051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000825
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