Exoerythrocytic Plasmodium Parasites Secrete a Cysteine Protease Inhibitor Involved in Sporozoite Invasion and Capable of Blocking Cell Death of Host Hepatocytes

Plasmodium parasites must control cysteine protease activity that is critical for hepatocyte invasion by sporozoites, liver stage development, host cell survival and merozoite liberation. Here we show that exoerythrocytic P. berghei parasites express a potent cysteine protease inhibitor (PbICP, P. b...

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Autori principali: Rennenberg, Annika, Lehmann, Christine, Heitmann, Anna, Witt, Tina, Hansen, Guido, Nagarajan, Krishna, Deschermeier, Christina, Turk, Vito, Hilgenfeld, Rolf, Heussler, Volker T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845656/
https://ncbi.nlm.nih.gov/pubmed/20361051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000825
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