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Molecular Mechanisms of T cell Receptor and Costimulatory Molecule Ligation/Blockade in Autoimmune Disease Therapy

Pro-inflammatory CD4(+) T cell mediated autoimmune diseases, such as multiple sclerosis and type 1 diabetes, are hypothesized to be initiated and maintained by activated antigen presenting cells (APCs) presenting self-antigen to self-reactive interferon-gamma (IFN-γ) and interleukin-17 (IL-17) produ...

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Bibliographic Details
Main Authors: Podojil, Joseph R., Miller, Stephen D.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845642/
https://ncbi.nlm.nih.gov/pubmed/19426232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-065X.2009.00773.x
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