Insulin gene VNTR genotype associates with frequency and phenotype of the autoimmune response to proinsulin

Immune responses to autoantigens are in part controlled by deletion of autoreactive cells through genetically regulated selection mechanisms. We have directly analyzed peripheral CD4+ proinsulin (PI) 76–90 (SLQPLALEGSLQKRG)-specific T cells using soluble fluorescent major histocompatibility complex...

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Detalhes bibliográficos
Main Authors: Durinovic-Belló, I, Wu, R P, Gersuk, V H, Sanda, S, Shilling, H G, Nepom, G T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Short Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845516/
https://ncbi.nlm.nih.gov/pubmed/20054344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2009.108
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