Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations.

The emergence of multidrug-resistant strains of Mycobacterium tuberculosis has resulted in increased interest in the fluoroquinolones (FQs) as antituberculosis agents. To investigate the frequency and mechanisms of FQ resistance in M. tuberculosis, we cloned and sequenced the wild-type gyrA and gyrB...

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Publicado en:Antimicrob Agents Chemother
Main Authors: Takiff, H E, Salazar, L, Guerrero, C, Philipp, W, Huang, W M, Kreiswirth, B, Cole, S T, Jacobs, W R, Telenti, A
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 1994
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284541/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8031045/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.4.773
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