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Mild folate deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cells

BACKGROUND: Folate (vitamin B9) is essential for cellular proliferation as it is involved in the biosynthesis of deoxythymidine monophosphate (dTMP) and s-adenosylmethionine (AdoMet). The link between folate depletion and the genesis and progression of cancers of epithelial origin is of high clinica...

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Detalhes bibliográficos
Main Authors: Bistulfi, Gaia, VanDette, Erika, Matsui, Sei-Ichi, Smiraglia, Dominic J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2845099/
https://ncbi.nlm.nih.gov/pubmed/20092614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-8-6
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