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Fever and associated changes in glomerular filtration rate erase anticipated diurnal variations in aminoglycoside pharmacokinetics.

Netilmicin (4.5 mg/kg of lean body weight) was administered intravenously once every 24 h at 10 a.m. to 23 patients (group I) and at 10 p.m. to 20 patients (group II) with severe infection. No significant differences (P > 0.05) in peak and trough concentrations in serum were found between groups I a...

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Publicado no:Antimicrob Agents Chemother
Principais autores: Fauvelle, F, Perrin, P, Belfayol, L, Boukari, M, Cherrier, P, Bosio, A M, Tod, M, Coulaud, J M, Petitjean, O
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284509/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8203864/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.3.620
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