Evaluation of the potent anti-hepatitis B virus agent (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine in a novel in vivo model.

A murine model was developed to investigate the in vivo activity of anti-hepatitis B virus (HBV) agents. Mice with subcutaneous tumors of HBV-producing 2.2.15 cells showed reductions in levels of HBV in serum and in intracellular levels of HBV when the mice were orally dosed with (-) cis-5-fluoro-1-...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Condreay, L D, Jansen, R W, Powdrill, T F, Johnson, L C, Selleseth, D W, Paff, M T, Daluge, S M, Painter, G R, Furman, P A, Ellis, M N
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284508/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7515609/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.3.616
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