The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase

Purine nucleoside phosphorylases and uridine phosphorylases are closely related enzymes involved in purine and pyrimidine salvage, respectively, which catalyze the removal of the ribosyl moiety from nucleosides so that the nucleotide base may be recycled. Parasitic protozoa generally are incapable o...

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Bibliografische gegevens
Hoofdauteurs: Larson, Eric T., Mudeppa, Devaraja G., Gillespie, J. Robert, Mueller, Natascha, Napuli, Alberto J., Arif, Jennifer A., Ross, Jenni, Arakaki, Tracy L., Lauricella, Angela, DeTitta, George, Luft, Joseph, Zucker, Frank, Verlinde, Christophe L. M. J., Fan, Erkang, Van Voorhis, Wesley C., Buckner, Frederick S., Rathod, Pradipsinh K., Hol, Wim G. J., Merritt, Ethan A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844865/
https://ncbi.nlm.nih.gov/pubmed/20070944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.01.013
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