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The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase

Purine nucleoside phosphorylases and uridine phosphorylases are closely related enzymes involved in purine and pyrimidine salvage, respectively, which catalyze the removal of the ribosyl moiety from nucleosides so that the nucleotide base may be recycled. Parasitic protozoa generally are incapable o...

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Detalhes bibliográficos
Main Authors: Larson, Eric T., Mudeppa, Devaraja G., Gillespie, J. Robert, Mueller, Natascha, Napuli, Alberto J., Arif, Jennifer A., Ross, Jenni, Arakaki, Tracy L., Lauricella, Angela, DeTitta, George, Luft, Joseph, Zucker, Frank, Verlinde, Christophe L. M. J., Fan, Erkang, Van Voorhis, Wesley C., Buckner, Frederick S., Rathod, Pradipsinh K., Hol, Wim G. J., Merritt, Ethan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844865/
https://ncbi.nlm.nih.gov/pubmed/20070944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.01.013
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