Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity

Plasmodium and other apicomplexan parasites are deficient in purine biosynthesis, relying instead on the salvage of purines from their host environment. Therefore interference with the purine salvage pathway is an attractive therapeutic target. The plasmodial enzyme adenosine deaminase (ADA) plays a...

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Bibliografiset tiedot
Päätekijät: Larson, Eric T., Deng, Wei, Krumm, Brian E., Napuli, Alberto, Mueller, Natascha, Van Voorhis, Wesley C., Buckner, Frederick S., Fan, Erkang, Lauricella, Angela, DeTitta, George, Luft, Joseph, Zucker, Frank, Hol, Wim G. J., Verlinde, Christophe L. M. J., Merritt, Ethan A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2600493/
https://ncbi.nlm.nih.gov/pubmed/18602399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.06.048
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