Recurrence of Type 1 Diabetes After Simultaneous Pancreas-Kidney Transplantation, Despite Immunosuppression, Is Associated With Autoantibodies and Pathogenic Autoreactive CD4 T-Cells

OBJECTIVE: To investigate if recurrent autoimmunity explained hyperglycemia and C-peptide loss in three immunosuppressed simultaneous pancreas-kidney (SPK) transplant recipients. RESEARCH DESIGN AND METHODS: We monitored autoantibodies and autoreactive T-cells (using tetramers) and performed biopsy....

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Autors principals: Vendrame, Francesco, Pileggi, Antonello, Laughlin, Elsa, Allende, Gloria, Martin-Pagola, Ainhoa, Molano, R. Damaris, Diamantopoulos, Stavros, Standifer, Nathan, Geubtner, Kelly, Falk, Ben A., Ichii, Hirohito, Takahashi, Hidenori, Snowhite, Isaac, Chen, Zhibin, Mendez, Armando, Chen, Linda, Sageshima, Junichiro, Ruiz, Phillip, Ciancio, Gaetano, Ricordi, Camillo, Reijonen, Helena, Nepom, Gerald T., Burke, George W., Pugliese, Alberto
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2010
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844842/
https://ncbi.nlm.nih.gov/pubmed/20086230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0498
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