The Natural Protective Mechanism Against Hyperglycemia in Vascular Endothelial Cells: Roles of the Lipid Peroxidation Product 4-Hydroxydodecadienal and Peroxisome Proliferator–Activated Receptor δ

OBJECTIVE: Vascular endothelial cells (VECs) downregulate their rate of glucose uptake in response to hyperglycemia by decreasing the expression of their typical glucose transporter GLUT-1. Hitherto, we discovered critical roles for the protein calreticulin and the arachidonic acid–metabolizing enzy...

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Main Authors: Riahi, Yael, Sin-Malia, Yoav, Cohen, Guy, Alpert, Evgenia, Gruzman, Arie, Eckel, Juergen, Staels, Bart, Guichardant, Michel, Sasson, Shlomo
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844828/
https://ncbi.nlm.nih.gov/pubmed/20107107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1207
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