Targeted Capture and Massively Parallel Sequencing of Twelve Human Exomes

Genome-wide association studies suggest that common genetic variants explain only a small fraction of heritable risk for common diseases, raising the question of whether rare variants account for a significant fraction of unexplained heritability1,2. While DNA sequencing costs have fallen dramatical...

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Hauptverfasser: Ng, Sarah B., Turner, Emily H., Robertson, Peggy D., Flygare, Steven D., Bigham, Abigail W., Lee, Choli, Shaffer, Tristan, Wong, Michelle, Bhattacharjee, Arindam, Eichler, Evan E., Bamshad, Michael, Nickerson, Deborah A., Shendure, Jay
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844771/
https://ncbi.nlm.nih.gov/pubmed/19684571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08250
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