Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signaling

Mutations in the E3 ubiquitin ligase parkin cause early onset autosomal recessive juvenile Parkinsonism (ARJP) presumably by having lack of function that alter the level, activity, aggregation or localization of its substrates. We recently reported that phospholipase Cγ1 (PLCγ1) is a substrate for p...

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Bibliografiska uppgifter
Huvudupphovsmän: Sandebring, Anna, Dehvari, Nodi, Perez-Manso, Monica, Thomas, Kelly Jean, Karpilovski, Elena, Cookson, Mark R., Cowburn, Richard F., Cedazo-Mínguez, Angel
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844703/
https://ncbi.nlm.nih.gov/pubmed/19663908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.07201.x
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