The Antidepressant Amitriptyline is a TrkA and TrkB Receptor Agonist that Promotes TrkA/TrkB Heterodimerization and Has Potent Neurotrophic Activity

Neurotrophins, the cognate ligands for the Trk receptors, are homodimers and induce Trk dimerization through a symmetric bivalent mechanism. We report here that amitriptyline, an antidepressant drug, directly binds TrkA and TrkB and triggers their dimerization and activation. Amitriptyline, but not...

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Autori principali: Jang, Sung-Wuk, Liu, Xia, Chan, Chi-Bun, Weinshenker, David, Hall, Randy A., Xiao, Ge, Ye, Keqiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844702/
https://ncbi.nlm.nih.gov/pubmed/19549602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.05.010
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