(6S)-6-fluoroshikimic acid, an antibacterial agent acting on the aromatic biosynthetic pathway.

(6S)-6-Fluoroshikimic acid inhibited the growth of Escherichia coli B on minimal medium (MIC, 0.25 micrograms ml-1), and it protected mice challenged intraperitoneally with the same organism (50% protective dose, 0.06 mg kg of body weight-1). We propose that inhibitors of bacterial aromatic biosynth...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Davies, G M, Barrett-Bee, K J, Jude, D A, Lehan, M, Nichols, W W, Pinder, P E, Thain, J L, Watkins, W J, Wilson, R G
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284469/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8192477/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.2.403
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