Glucocorticoid receptor knock down reveals a similar apoptotic threshold but differing gene regulation patterns in T-cell and pre-B-cell acute lymphoblastic leukemia

Glucocorticoids (GCs) are used in combination therapy for treating acute lymphoblastic leukemia (ALL). In T-cell (CEM-C7) and pre-B-cell (697) ALL cell lines, dexamethasone (Dex) treatment causes an auto-upregulation of glucocorticoid receptor (GR) mRNA transcripts and protein. We hypothesized that...

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Hlavní autoři: Schwartz, Jason R., Sarvaiya, Purvaba J., Vedeckis, Wayne V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844487/
https://ncbi.nlm.nih.gov/pubmed/20170710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2010.02.014
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