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Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine.

The technique of in vitro selection was used to generate variants of the human immunodeficiency virus type 1 that are resistant to 2',3'-dideoxycytidine (ddC). Most of the pol regions of such viruses, including the complete reverse transcriptase open reading frame and portions of flanking...

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Détails bibliographiques
Auteurs principaux: Gu, Z, Gao, Q, Fang, H, Salomon, H, Parniak, M A, Goldberg, E, Cameron, J, Wainberg, M A
Format: Artigo
Langue:Inglês
Publié: 1994
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC284440/
https://ncbi.nlm.nih.gov/pubmed/7514855
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