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Role of intramembrane charged residues in the quality control of unassembled T-cell receptor α-chains at the endoplasmic reticulum
Endoplasmic reticulum (ER)-associated degradation (ERAD) of unassembled T-cell receptor α-chain (TCRα) is reliant on the presence of two basic residues in the transmembrane (TM) segment of TCRα. The precise role of these residues in ER quality control is unclear. Here, we show that a TCRα mutant lac...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Company of Biologists
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2844315/ https://ncbi.nlm.nih.gov/pubmed/20332119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.059758 |
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