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Genetic alterations in streptomycin-resistant Mycobacterium tuberculosis: mapping of mutations conferring resistance.

We report on the identification of mutations associated with streptomycin resistance in Mycobacterium tuberculosis. Two isolates (3656 and 3976) showed a wild-type ribosomal protein, S12, but exhibited a single point mutation at 16S rRNA position 491 (C-->T) or 512 (C-->T), respectively. Sequence an...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Meier, A, Kirschner, P, Bange, F C, Vogel, U, Böttger, E C
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284431/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8192448/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.2.228
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