siRNA-Based Therapy Ameliorates Glomerulonephritis

RNA interference by short interfering RNAs (siRNAs) holds promise as a therapeutic strategy, but use of siRNAs in vivo remains limited. Here, we developed a system to target delivery of siRNAs to glomeruli via poly(ethylene glycol)-poly(l-lysine)-based vehicles. The siRNA/nanocarrier complex was app...

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Bibliographische Detailangaben
Hauptverfasser: Shimizu, Hideki, Hori, Yuichi, Kaname, Shinya, Yamada, Koei, Nishiyama, Nobuhiro, Matsumoto, Satoru, Miyata, Kanjiro, Oba, Makoto, Yamada, Akira, Kataoka, Kazunori, Fujita, Toshiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2010
Schlagworte:
Basic Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844303/
https://ncbi.nlm.nih.gov/pubmed/20203158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009030295
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