Different ratios of the piperacillin-tazobactam combination for treatment of experimental meningitis due to Klebsiella pneumoniae producing the TEM-3 extended-spectrum beta-lactamase.

We evaluated the pharmacokinetics and therapeutic efficacies of piperacillin and tazobactam, a beta-lactamase inhibitor, given either alone or in different combinations (80:10, 200:10, and 80:25 mg/kg/h), in experimental meningitis due to a strain of Klebsiella pneumoniae producing the TEM-3 extende...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Leleu, G, Kitzis, M D, Vallois, J M, Gutmann, L, Decazes, J M
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1994
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284425/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8192442/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.38.2.195
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