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Site-specific Phosphorylation of CXCR4 Is Dynamically Regulated by Multiple Kinases and Results in Differential Modulation of CXCR4 Signaling

The chemokine receptor CXCR4 is a widely expressed G protein-coupled receptor that has been implicated in a number of diseases including human immunodeficiency virus, cancer, and WHIM syndrome, with the latter two involving dysregulation of CXCR4 signaling. To better understand the role of phosphory...

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Detalhes bibliográficos
Main Authors: Busillo, John M., Armando, Sylvain, Sengupta, Rajarshi, Meucci, Olimpia, Bouvier, Michel, Benovic, Jeffrey L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844224/
https://ncbi.nlm.nih.gov/pubmed/20048153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.091173
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