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A Pivot between Helices V and VI near the Retinal-binding Site Is Necessary for Activation in Rhodopsins
Rhodopsins are photoreceptor proteins that have diverged from ligand-binding G protein-coupled receptors (GPCRs). Unlike other GPCRs, rhodopsins contain an intrinsic antagonist, 11-cis-retinal, which is converted to the agonist all-trans-retinal upon absorption of a photon. Through evolution, verteb...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2844183/ https://ncbi.nlm.nih.gov/pubmed/20053991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.078709 |
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