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A Pivot between Helices V and VI near the Retinal-binding Site Is Necessary for Activation in Rhodopsins

Rhodopsins are photoreceptor proteins that have diverged from ligand-binding G protein-coupled receptors (GPCRs). Unlike other GPCRs, rhodopsins contain an intrinsic antagonist, 11-cis-retinal, which is converted to the agonist all-trans-retinal upon absorption of a photon. Through evolution, verteb...

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Detaylı Bibliyografya
Asıl Yazarlar: Tsukamoto, Hisao, Terakita, Akihisa, Shichida, Yoshinori
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844183/
https://ncbi.nlm.nih.gov/pubmed/20053991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.078709
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