Oxaliplatin, irinotecan and capecitabine as first-line therapy in metastatic colorectal cancer (mCRC): a dose-finding study and pharmacogenomic analysis

BACKGROUND: A dose-finding study was performed to evaluate the dose-limiting toxicity (DLT), maximum-tolerated dose (MTD) and the recommended dose (RD) of escalating the doses of capecitabine and fixed doses of irinotecan and oxaliplatin on a biweekly schedule for metastatic colorectal cancer patien...

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Bibliographic Details
Main Authors: Zarate, R, Rodríguez, J, Bandres, E, Patiño-Garcia, A, Ponz-Sarvise, M, Viudez, A, Ramirez, N, Bitarte, N, Chopitea, A, Gacía-Foncillas, J
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2010
Subjects:
Clinical Study
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844042/
https://ncbi.nlm.nih.gov/pubmed/20216541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605595
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